Bioscience & Engineering: An International Journal (BIOEJ)

ISSN : 2349- 848X

http://airccse.com/bioej/index.html

paper submission :-

http://allcfps.com/noncs/submission/index.php

Submission Deadline : January 12, 2019

Contact Us : bioej@airccse.com

Qsar Studies on Gallic Acid Derivatives and Molecular Docking Studies of Bace1 Enzyme – A Potent Target of Alzheimer Disease.

KrishnaKant Gupta1

1 PhD Research Scholar, Center for Bioinformatics, Pondicherry University, Pondicherry, India,

Abstract

It is reported that Alzheimer disease is linked with hypertension, diabetes type 2 and high cholesterolemia. The underlying genetic cause relating these diseases are not well studied clinically. But it has been widely accepted that beta secretase (BACE1) is the main culprit of causing Alzheimer disease. This enzyme comes under peptidase A1 family. In the present work, ligand based and structure based drug designing have been reported. QSAR studies were done using 21 gallic acid derivatives dataset to develop good predictive model in order to predict biological activity and certain descriptors was reported to further enhance the analgesic activity of gallic acid derivatives. Molecular docking studies were performed in order to find structure based drug design. Two natural gallic acid derivative have been repoted as a potent inhibitor to beta secretase enzyme.

Keywords:

Alzheimer Disease, beta secretase, QSAR, Molecular docking, Ligands, inhibitor.

Bioscience & Engineering: An International Journal (BIOEJ)

ISSN : 2349- 848X

http://airccse.com/bioej/index.html

Scope & Topics

Bioscience & Engineering: An International Journal (BIOEJ) is a peer-reviewed, open access journal that addresses the impacts and challenges of Bioscience, Bioengineering and Applications. The journal documents practical and theoretical results which make a fundamental contribution for the development of Bioscience & Engineering.

This journal aims to bring together researchers and practitioners in all Bioscience & Engineering aspects, including (but not limited to)

Topic of Interest :

• Biochemical Engineering
• Biochemistry
• Bioinformatics
• Health Informatics
• Biomedicine
• Bioscience Engineering
• Biotechnology
• Bio-fermentation Technology
• Food Science & Technology
• Genetics
• Geomicrobiology
• Microbiology
• Molecular Biology of Plants
• Zoo physiology

Paper Submission

Authors are invited to submit papers for this journal through Submission System.  Submissions must be original and should not have been published previously or be under consideration for publication while being evaluated for this Journal.

Important Dates

• Submission Deadline : January 12, 2019
• Notification                   : February 12, 2019
• Final Manuscript Due : February 20, 2019
• Publication Date          : Determined by the Editor-in-Chief

Contact Us

Here's where you can reach us : bioej@airccse.com

WIKICFP LINK:

http://www.wikicfp.com/cfp/servlet/event.showcfp?eventid=69762

Bioscience & Engineering: An International Journal (BIOEJ)

ISSN : 2349- 848X

http://airccse.com/bioej/index.html

paper submission :-

http://allcfps.com/noncs/submission/index.php

Submission Deadline : January 12, 2019

Contact Us : bioej@airccse.com

WHY JUST TEACH ART: THE DEVELOPMENT OF

THE HIPPOCAMPUS

Judson Wright Pump Orgin, New York, USA

ABSTRACT

That we intuitively feel a need to teach children what we consider the rudiments of education, approximately as soon as they are socially adept enough to attend school is not unjustified (eg. the “core

curriculum standards” adopted by US public schools). However, there is a deeper technical issue to be considered, one that proves remarkably simple. Though the role of the hippocampus, within the larger function of the brain, is hardly well understood, there is ample evidence of its role in a particular aspect of

memory, namely metacognition, or “knowing about knowing.” More neurologically informed consideration for the distinct memory systems that contribute to cognition revels that these rudiments may be entirely artificial and based on “adult-centric” conceptual frames. Moreover, given that the hippocampus is only fully formed by early adulthood, this would indicate that our educational itinerary may easily be fundamentally flawed, and at least warrants radical reconsideration.

KEYWORDS

art education, concept development, hippocampus, memory systems

https://airccse.com/bioej/papers/1114bioej01.pdf

Bioscience & Engineering: An International Journal (BIOEJ)

ISSN : 2349- 848X

http://airccse.com/bioej/index.html

paper submission :-

http://allcfps.com/noncs/submission/index.php

Submission Deadline : January 12, 2019

Contact Us : bioej@airccse.com